|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The elevated expression of SYNE1, MMP10, and MTG1 suggests the role of these proteins as potential players in HCC progression and tumorigenesis.
|
31428857 |
2020 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The elevated expression of SYNE1, MMP10, and MTG1 suggests the role of these proteins as potential players in HCC progression and tumorigenesis.
|
31428857 |
2020 |
|
Malignant Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Ras‑associated protein 1A (Rap1A) is a member of the Ras subfamily of small GTP‑binding proteins and is found to promote metastasis in several types of cancer.
|
31545475 |
2019 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
p21<sup>ras</sup> protein activity, regulated by GTP hydrolysis, constitutes an active field of research for the development of cancer targeted therapies that would concern ∼30% of human tumors to which specific mutations have been associated.
|
30991803 |
2019 |
|
Primary malignant neoplasm
|
0.060 |
AlteredExpression
|
group |
BEFREE |
p21<sup>ras</sup> protein activity, regulated by GTP hydrolysis, constitutes an active field of research for the development of cancer targeted therapies that would concern ∼30% of human tumors to which specific mutations have been associated.
|
30991803 |
2019 |
|
Primary malignant neoplasm
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Ras‑associated protein 1A (Rap1A) is a member of the Ras subfamily of small GTP‑binding proteins and is found to promote metastasis in several types of cancer.
|
31545475 |
2019 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
p21<sup>ras</sup> protein activity, regulated by GTP hydrolysis, constitutes an active field of research for the development of cancer targeted therapies that would concern ∼30% of human tumors to which specific mutations have been associated.
|
30991803 |
2019 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
We measured TUFT1, Rab5-GTP, and Rac1-GTP expression levels in samples of human TNBC by immunohistochemistry (IHC) and conducted univariate and multivariate analyses. shRNA-mediated knockdown and overexpression, combined with transwell assays, co-immunoprecipitation, a nude mouse xenograft tumor model, and GTP activity assays were used for further mechanistic studies.
|
31572059 |
2019 |
|
Hepatitis C
|
0.020 |
Biomarker
|
disease |
BEFREE |
Molecular dynamics and docking reveal the potency of novel GTP derivatives against RNA dependent RNA polymerase of genotype 4a HCV.
|
31628915 |
2019 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Ras‑associated protein 1A (Rap1A) is a member of the Ras subfamily of small GTP‑binding proteins and is found to promote metastasis in several types of cancer.
|
31545475 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Recent advances in our understanding of the mechanistic role of IMPDH in tumorigenesis and cancer progression, as well as the development of IMPDH inhibitors with selective actions on GTP synthesis, have prompted a reappraisal of targeting this enzyme for anti-cancer treatment.
|
31514446 |
2019 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Western blot assay demonstrated that KIF18B knockdown markedly decreased Rac1-GTP expression, an important marker of migration and invasion in tumors.
|
31759406 |
2019 |
|
Triple Negative Breast Neoplasms
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Further, TUFT1 expression positively correlated with Rac1-GTP in TNBC samples, and co-expression of TUFT1 and Rac1-GTP predicted poor prognosis in TNBC patients who treated with chemotherapy.
|
31338333 |
2019 |
|
Triple Negative Breast Neoplasms
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
TUFT1 expression was positively correlated with Rab5-GTP and Rac1-GTP in the TNBC samples, and co-expression of TUFT1 and Rab5-GTP predicted poor prognosis in TNBC patients who were treated with chemotherapy.
|
31572059 |
2019 |
|
Peri-implant mucositis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Eighty individuals diagnosed with PM (T1) and followed during 5 years (T2) were divided into one group with PMT during the study period (GTP; n = 39) and another group without PMT (GNTP; n = 41).
|
30386996 |
2019 |
|
Peri-implant mucositis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
All individuals (n=12) who presented peri-implant mucositis and had resolution at T2 were in the GTP group.
|
30810638 |
2019 |
|
Triple-Negative Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
TUFT1 expression was positively correlated with Rab5-GTP and Rac1-GTP in the TNBC samples, and co-expression of TUFT1 and Rab5-GTP predicted poor prognosis in TNBC patients who were treated with chemotherapy.
|
31572059 |
2019 |
|
Triple-Negative Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Further, TUFT1 expression positively correlated with Rac1-GTP in TNBC samples, and co-expression of TUFT1 and Rac1-GTP predicted poor prognosis in TNBC patients who treated with chemotherapy.
|
31338333 |
2019 |
|
Biliary Atresia
|
0.010 |
Biomarker
|
disease |
BEFREE |
<sup>99m</sup>Tc-PMT scintigraphy, stool color change, total bilirubin, direct bilirubin, aspartate aminotransferase (AST) and γ-glutamyl transferase (γ-GTP) led to distinguishing between BA and non-BA in univariate analysis.
|
31571132 |
2019 |
|
Fatty Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
We evaluated changes in aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (γ-GTP), alkaline phosphatase (ALP), and fatty liver index (FLI) at 3 months of treatment; the proportion of patients with abnormal liver function whose liver function normalized after 3 months of treatment; and correlations between changes in ALT levels and efficacy variables/laboratory values.
|
30393249 |
2019 |
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
To examine the role of MTG1 in cardiac hypertrophy and heart failure, MTG1 loss/gain of function studies were performed in cultured cardiomyocytes and mice exposed to hypertrophic stress.
|
30707992 |
2019 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
To examine the role of MTG1 in cardiac hypertrophy and heart failure, MTG1 loss/gain of function studies were performed in cultured cardiomyocytes and mice exposed to hypertrophic stress.
|
30707992 |
2019 |
|
Lymphoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In the absence of WASP, active GTP-bound CDC42 was increased and the genetic deletion of one CDC42 allele was sufficient to impair lymphoma growth.
|
30510251 |
2019 |
|
Noonan Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We show that the NS-causing RRAS2 variants affect highly conserved residues localized around the nucleotide binding pocket of the GTPase and are predicted to variably affect diverse aspects of RRAS2 biochemical behavior, including nucleotide binding, GTP hydrolysis, and interaction with effectors.
|
31130282 |
2019 |
|
Periodontitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
After 5 years, there was an increase in the incidence of periodontitis in the GNTP group compared to the GTP group (p=0.001).
|
30810638 |
2019 |